{"id":5785,"date":"2024-08-05T20:08:56","date_gmt":"2024-08-05T20:08:56","guid":{"rendered":"http:\/\/genetikascentrs.lv\/services\/eksoma-sekvencesana\/"},"modified":"2024-10-10T16:38:18","modified_gmt":"2024-10-10T16:38:18","slug":"eksoma-sekvencesana","status":"publish","type":"page","link":"https:\/\/genetikascentrs.lv\/en\/services\/eksoma-sekvencesana\/","title":{"rendered":"Exome Sequencing"},"content":{"rendered":"[vc_row rsclass=&#8221;clean&#8221; el_class=&#8221;row&#8221;][vc_column width=&#8221;1\/4&#8243; rsclass=&#8221;clean&#8221; el_class=&#8221;col-md&#8221;][vc_wp_custommenu nav_menu=&#8221;64&#8243; el_class=&#8221;services-nav flex-column flex-nowrap&#8221;][vc_row_inner rsclass=&#8221;clean&#8221; el_class=&#8221;row d-flex flex-column flex-sm-row flex-md-column mt-3&#8243;][vc_column_inner el_class=&#8221;col-auto col-sm col-md-auto&#8221; rsclass=&#8221;clean&#8221; rsinner=&#8221;contact-box contact-box-1&#8243;][vc_custom_heading text=&#8221;Working Time&#8221; font_container=&#8221;tag:h5|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221; rs_decor_place=&#8221;2&#8243; el_class=&#8221;contact-box-title&#8221;][\/vc_custom_heading][vc_column_text rsclass=&#8221;clean&#8221;]\n<ul class=\"icn-list\">\n<li><svg class=\"icon icon-clock\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\"><title>clock<\/title><path d=\"M20.655 15.582h-4.232v-4.232c0-0.701-0.569-1.27-1.27-1.27s-1.27 0.569-1.27 1.27v5.502c0 0.701 0.569 1.27 1.27 1.27h5.502c0.701 0 1.27-0.569 1.27-1.27s-0.569-1.27-1.27-1.27z\"><\/path><path d=\"M16 1.5c-7.995 0-14.5 6.505-14.5 14.5s6.505 14.5 14.5 14.5 14.5-6.505 14.5-14.5c0-7.995-6.505-14.5-14.5-14.5zM16 27.96c-6.595 0-11.96-5.365-11.96-11.96s5.365-11.96 11.96-11.96 11.96 5.365 11.96 11.96c0 6.595-5.365 11.96-11.96 11.96z\"><\/path><\/svg>Mon-Thu <b>08:00 &#8211; 20:00<\/b><br class=\"tt\" \/>Friday <b>07:00 &#8211; 22:00<\/b><br class=\"tt\" \/>Saturday <b>08:00 &#8211; 18:00<\/b><\/li>\n<\/ul>\n[\/vc_column_text][\/vc_column_inner][vc_column_inner el_class=&#8221;col-auto col-sm col-md-auto&#8221; rsclass=&#8221;clean&#8221; rsinner=&#8221;contact-box contact-box-2&#8243;][vc_custom_heading text=&#8221;Contact Info&#8221; font_container=&#8221;tag:h5|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221; rs_decor_place=&#8221;2&#8243; el_class=&#8221;contact-box-title&#8221;][\/vc_custom_heading][vc_column_text rsclass=&#8221;clean&#8221;]\n<ul class=\"icn-list\">\n<li class=\" p-l-0\">\n<div class=\"tt\"><svg class=\"icon icon-clock\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\"><title>clock<\/title><path d=\"M20.655 15.582h-4.232v-4.232c0-0.701-0.569-1.27-1.27-1.27s-1.27 0.569-1.27 1.27v5.502c0 0.701 0.569 1.27 1.27 1.27h5.502c0.701 0 1.27-0.569 1.27-1.27s-0.569-1.27-1.27-1.27z\"><\/path><path d=\"M16 1.5c-7.995 0-14.5 6.505-14.5 14.5s6.505 14.5 14.5 14.5 14.5-6.505 14.5-14.5c0-7.995-6.505-14.5-14.5-14.5zM16 27.96c-6.595 0-11.96-5.365-11.96-11.96s5.365-11.96 11.96-11.96 11.96 5.365 11.96 11.96c0 6.595-5.365 11.96-11.96 11.96z\"><\/path><\/svg><span class=\"tt\">Phone: <\/span><span class=\"tt\"><b>1-800-267-0000<\/b><br \/>\n<b class=\"p-l-86\">1-800-267-0001<\/b><\/span><\/div>\n<\/li>\n<li class=\" p-l-0\">\n<div class=\"tt\"><svg class=\"icon icon-black-envelope\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\"><title>black-envelope<\/title><path d=\"M2.531 6.124l11.526 9.13c0.523 0.414 1.243 0.597 1.942 0.563 0.698 0.034 1.419-0.148 1.941-0.563l11.526-9.13c0.924-0.727 0.715-1.323-0.457-1.323h-26.019c-1.173 0-1.382 0.596-0.461 1.323z\"><\/path><path d=\"M30.3 8.533l-12.596 9.563c-0.471 0.354-1.088 0.526-1.702 0.518-0.616 0.008-1.233-0.165-1.704-0.518l-12.598-9.563c-0.935-0.709-1.7-0.329-1.7 0.844v15.69c0 1.173 0.96 2.133 2.133 2.133h27.734c1.173 0 2.133-0.96 2.133-2.133v-15.69c0-1.173-0.765-1.553-1.7-0.844z\"><\/path><\/svg><a href=\"mailto:info@dentco.net\">info@dentco.net<\/a><\/div>\n<\/li>\n<\/ul>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner rsclass=&#8221;clean&#8221;][vc_column_inner el_class=&#8221;question-box mt-3&#8243; rsclass=&#8221;clean&#8221;][vc_custom_heading text=&#8221;Ask the Experts&#8221; font_container=&#8221;tag:h5|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221; rs_decor_place=&#8221;2&#8243; el_class=&#8221;question-box-title&#8221;][\/vc_custom_heading]\n<div class=\"wpcf7 no-js\" id=\"wpcf7-f246-o1\" lang=\"en-US\" dir=\"ltr\" data-wpcf7-id=\"246\">\n<div class=\"screen-reader-response\"><p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/p> <ul><\/ul><\/div>\n<form action=\"\/en\/wp-json\/wp\/v2\/pages\/5785#wpcf7-f246-o1\" method=\"post\" class=\"wpcf7-form init\" aria-label=\"Contact form\" novalidate=\"novalidate\" data-status=\"init\">\n<div style=\"display: none;\">\n<input type=\"hidden\" name=\"_wpcf7\" value=\"246\" \/>\n<input type=\"hidden\" name=\"_wpcf7_version\" value=\"6.0.4\" \/>\n<input type=\"hidden\" name=\"_wpcf7_locale\" value=\"en_US\" \/>\n<input type=\"hidden\" name=\"_wpcf7_unit_tag\" value=\"wpcf7-f246-o1\" \/>\n<input type=\"hidden\" name=\"_wpcf7_container_post\" value=\"0\" \/>\n<input type=\"hidden\" name=\"_wpcf7_posted_data_hash\" value=\"\" \/>\n<input type=\"hidden\" name=\"_wpcf7_recaptcha_response\" value=\"\" \/>\n<\/div>\n<div class=\"contact-form contact7__custom-form questionForm ws-form-icons7\" id=\"questionForm\">\n\t<div class=\"input-group\">\n\t\t<p><span class=\"wpcf7-form-control-wrap\" data-name=\"your-name\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text form-control\" aria-invalid=\"false\" placeholder=\"Your name\" value=\"\" type=\"text\" name=\"your-name\" \/><\/span>\n\t\t<\/p>\n\t<\/div>\n\t<div class=\"row row-xs-space7 mt-0 mt-md-1\">\n\t\t<div class=\"col-sm-6\">\n\t\t\t<div class=\"input-group\">\n\t\t\t\t<p><span class=\"wpcf7-form-control-wrap\" data-name=\"your-email\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-email wpcf7-text wpcf7-validates-as-email form-control\" aria-invalid=\"false\" placeholder=\"Your e-mail\" value=\"\" type=\"email\" name=\"your-email\" \/><\/span>\n\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"col-sm-6\">\n\t\t\t<div class=\"input-group\">\n\t\t\t\t<p><span class=\"wpcf7-form-control-wrap\" data-name=\"your-phone\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text form-control\" aria-invalid=\"false\" placeholder=\"Phone\" value=\"\" type=\"text\" name=\"your-phone\" \/><\/span>\n\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\t<div class=\"mt-0 mt-md-1\">\n\t\t<p><span class=\"wpcf7-form-control-wrap\" data-name=\"your-message\"><textarea cols=\"40\" rows=\"10\" maxlength=\"2000\" class=\"wpcf7-form-control wpcf7-textarea wpcf7-validates-as-required form-control form-control-textarea\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Question*\" name=\"your-message\"><\/textarea><\/span>\n\t\t<\/p>\n\t<\/div>\n\t<div class=\"form-ask_btn_c\">\n\t\t<div class=\"mt-2\">\n\t\t\t<p><input class=\"wpcf7-form-control wpcf7-submit has-spinner btn btn-fill\" type=\"submit\" value=\"Send question\" \/>\n\t\t\t<\/p>\n\t\t<\/div>\n\t<\/div>\n<\/div><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div>\n<\/form>\n<\/div>\n[\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column width=&#8221;3\/4&#8243; rsclass=&#8221;clean&#8221; el_class=&#8221;col-md-8 col-lg-9 mt-4 mt-md-0&#8243;][vc_row_inner rsclass=&#8221;clean&#8221; el_class=&#8221;pt-2 pt-md-4&#8243;][vc_column_inner rsclass=&#8221;clean&#8221;][vc_column_text rsclass=&#8221;clean&#8221;]\n<h3><b>Hereditary recessive disease panel<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Ability to identify carrier status for recessive genetic disorders, allowing individuals or couples to make informed decisions about family planning, reduce the risk of passing on inherited diseases to their children, and access appropriate genetic counselling and reproductive options.<\/span><\/p>\n<p><b>Indications:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Family history of recessive genetic disorders<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Consanguineous relationships<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ethnic or population-specific genetic risks<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Unexplained infertility or recurrent pregnancy loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Personal or Partner&#8217;s Medical History<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">This knowledge empowers individuals to make informed decisions about their reproductive health and family planning.<\/span><\/p>\n<p><b>Early Detection of Carrier Status &#8211; Risk Assessment for Baby &#8211; Guidance for Genetic Counselling<\/b><\/p>\n<h3><b>Test for poor responder &#8211; The Early Menopause Panel<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Diagnostic test used to assess ovarian reserve and predict the likelihood of early menopause in women, particularly those who may be experiencing fertility challenges or are at risk of premature ovarian insufficiency.<\/span><\/p>\n<p><b>Indications:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">for women over 35 who are not yet planning a pregnancy<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">if premature ovarian failure has been diagnosed \u2013 to understand how to act correctly for family planning<\/span><\/li>\n<\/ul>\n<p><b>Early Detection of Ovarian Dysfunction &#8211; Assessment of Fertility Potential &#8211; Predictive Value for Early Menopause &#8211; Personalized Treatment Planning &#8211; Preservation of the genetic material<\/b><\/p>\n<h3><b>Genetic predisposition of embryonic development abnormalities<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Changes in the certain genes can be one of the reasons why egg fertilization is unsuccessful, the development of the embryo (blastocyst) stops or is arrested, or pregnancy does not occur, even if the embryo (blastocyst) has developed to the necessary stage for transfer.<\/span><\/p>\n<p><b>Indications:<\/b><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">out of several eggs, only a few were fertilized, and the development of embryos (blastocysts) did not take place<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">embryos (blastocysts) were growing until the third day, transfer was performed, but pregnancy did not occur.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">embryo (blastocyst) development stopped until day 5 and transfer was not possible<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><span style=\"font-weight: 400;\">only a few embryos (blastocysts) from several fertilized eggs developed until the fifth day <\/span><b>and the transfer was performed, but pregnancy did not occur<\/b><\/li>\n<\/ul>\n<p><b>Assessment of Fertility Potential &#8211; Personalized Treatment Planning &#8211; Guidance for Genetic Counselling<\/b><\/p>\n<h3><b>Test before TESE procedure &#8211; Disorders of Spermatogenesis Panel<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Panel offers valuable insights into the genetic factors contributing to male infertility\u00a0<\/span><\/p>\n<p><b>Indication:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Non-obstructive azoospermia in patients with normal karyotype and negative Y chromosome deletions.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">These patients are usually referred to the TESE procedure with an average sperm retrieval success rate of 50%.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">However, before the TESE procedure, an NGS can be suggested &#8211; for the targeted genes that are known to be associated with Sertoli cell-only syndrome, or sperm maturation arrest, or other spermatogenesis disorders that will result in negative TESE outcome. Therefore, it will assist to select the patients for whom TESE will not be effective and save them from unnecessary interventions.<\/span><\/p>\n<p><b>Evaluation of Infertility &#8211; Personalized Treatment Planning &#8211; Risk Assessment for Baby &#8211; Guidance for Genetic Counselling<\/b><\/p>\n<h3><b>Most common hereditary cancer gene panel: 33 genes<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Detects changes in 33 genes associated with hereditary tumour syndromes. The advantage of this panel is its wide diagnostic capabilities, which, when suspected of hereditary tumour syndromes, can not only determine changes in certain syndrome-related genes, but also expand the range of tested genes, including genes, whose changes can occur phenotypically as tumours less typical for the syndrome.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This panel is recommended for hereditary breast \/ ovarian cancer, as well as in the case of various other tumours, such as Lynch syndrome, or hereditary nonpolyposis colorectal cancer, Li-Fraumeni syndrome, Cowden syndrome, Multiple endocrine neoplasia (MEN), various kinds of hereditary intestinal polyposis with high risk of malignancies, Neurofibromatosis type 1 (NF1).\u00a0<\/span>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_empty_space][vc_column_text]Sign up: <strong>+371 67111117<\/strong> or <strong><a href=\"mailto:genetikascentrs@ivfriga.eu\" target=\"_blank\" rel=\"noopener noreferrer\">genetikascentrs@ivfriga.eu<\/a><\/strong>[\/vc_column_text][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"<p>[vc_row rsclass=&#8221;clean&#8221; el_class=&#8221;row&#8221;][vc_column width=&#8221;1\/4&#8243; rsclass=&#8221;clean&#8221; el_class=&#8221;col-md&#8221;][vc_wp_custommenu nav_menu=&#8221;64&#8243; el_class=&#8221;services-nav flex-column flex-nowrap&#8221;][vc_row_inner rsclass=&#8221;clean&#8221; el_class=&#8221;row d-flex flex-column flex-sm-row flex-md-column mt-3&#8243;][vc_column_inner el_class=&#8221;col-auto col-sm col-md-auto&#8221; rsclass=&#8221;clean&#8221; rsinner=&#8221;contact-box contact-box-1&#8243;][vc_custom_heading text=&#8221;Working Time&#8221; font_container=&#8221;tag:h5|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221; rs_decor_place=&#8221;2&#8243; el_class=&#8221;contact-box-title&#8221;][\/vc_custom_heading][vc_column_text rsclass=&#8221;clean&#8221;] Mon-Thu 08:00 &#8211; 20:00Friday 07:00 &#8211; 22:00Saturday 08:00 &#8211; 18:00 [\/vc_column_text][\/vc_column_inner][vc_column_inner el_class=&#8221;col-auto col-sm col-md-auto&#8221; rsclass=&#8221;clean&#8221; rsinner=&#8221;contact-box contact-box-2&#8243;][vc_custom_heading text=&#8221;Contact Info&#8221; 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