{"id":5505,"date":"2023-04-26T18:45:56","date_gmt":"2023-04-26T18:45:56","guid":{"rendered":"http:\/\/genetikascentrs.lv\/iedzimta-virsnieru-hiperplazija-cyp21a2-gena-molekulara-testesana\/"},"modified":"2024-03-15T12:45:11","modified_gmt":"2024-03-15T12:45:11","slug":"congenital-adrenal-hyperplasia","status":"publish","type":"page","link":"https:\/\/genetikascentrs.lv\/en\/services\/genetic-analyses\/congenital-adrenal-hyperplasia\/","title":{"rendered":"Congenital adrenal hyperplasia:"},"content":{"rendered":"[vc_row][vc_column][vc_column_text rsclass=&#8221;clean&#8221;]\n<h1 style=\"text-align: center;\">Molecular testing of the CYP21A2 gene<\/h1>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row rsclass=&#8221;clean&#8221; el_class=&#8221;row&#8221;][vc_column width=&#8221;1\/4&#8243; rsclass=&#8221;clean&#8221; el_class=&#8221;col-md&#8221;][vc_wp_custommenu nav_menu=&#8221;64&#8243; el_class=&#8221;services-nav flex-column flex-nowrap&#8221;][vc_row_inner rsclass=&#8221;clean&#8221; el_class=&#8221;row d-flex flex-column flex-sm-row flex-md-column mt-3&#8243;][vc_column_inner el_class=&#8221;col-auto col-sm col-md-auto&#8221; rsclass=&#8221;clean&#8221; rsinner=&#8221;contact-box contact-box-1&#8243;][vc_custom_heading text=&#8221;Working Time&#8221; font_container=&#8221;tag:h5|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221; rs_decor_place=&#8221;2&#8243; el_class=&#8221;contact-box-title&#8221;][\/vc_custom_heading][vc_column_text rsclass=&#8221;clean&#8221;]\n<ul class=\"icn-list\">\n<li><svg class=\"icon icon-clock\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\"><title>clock<\/title><path d=\"M20.655 15.582h-4.232v-4.232c0-0.701-0.569-1.27-1.27-1.27s-1.27 0.569-1.27 1.27v5.502c0 0.701 0.569 1.27 1.27 1.27h5.502c0.701 0 1.27-0.569 1.27-1.27s-0.569-1.27-1.27-1.27z\"><\/path><path d=\"M16 1.5c-7.995 0-14.5 6.505-14.5 14.5s6.505 14.5 14.5 14.5 14.5-6.505 14.5-14.5c0-7.995-6.505-14.5-14.5-14.5zM16 27.96c-6.595 0-11.96-5.365-11.96-11.96s5.365-11.96 11.96-11.96 11.96 5.365 11.96 11.96c0 6.595-5.365 11.96-11.96 11.96z\"><\/path><\/svg>Mon-Thu <b>08:00 &#8211; 20:00<\/b><br class=\"tt\" \/>Friday <b>07:00 &#8211; 22:00<\/b><br class=\"tt\" \/>Saturday <b>08:00 &#8211; 18:00<\/b><\/li>\n<\/ul>\n[\/vc_column_text][\/vc_column_inner][vc_column_inner el_class=&#8221;col-auto col-sm col-md-auto&#8221; rsclass=&#8221;clean&#8221; rsinner=&#8221;contact-box contact-box-2&#8243;][vc_custom_heading text=&#8221;Contact Info&#8221; font_container=&#8221;tag:h5|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221; rs_decor_place=&#8221;2&#8243; el_class=&#8221;contact-box-title&#8221;][\/vc_custom_heading][vc_column_text rsclass=&#8221;clean&#8221;]\n<ul class=\"icn-list\">\n<li class=\" p-l-0\">\n<div class=\"tt\"><svg class=\"icon icon-clock\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\"><title>clock<\/title><path d=\"M20.655 15.582h-4.232v-4.232c0-0.701-0.569-1.27-1.27-1.27s-1.27 0.569-1.27 1.27v5.502c0 0.701 0.569 1.27 1.27 1.27h5.502c0.701 0 1.27-0.569 1.27-1.27s-0.569-1.27-1.27-1.27z\"><\/path><path d=\"M16 1.5c-7.995 0-14.5 6.505-14.5 14.5s6.505 14.5 14.5 14.5 14.5-6.505 14.5-14.5c0-7.995-6.505-14.5-14.5-14.5zM16 27.96c-6.595 0-11.96-5.365-11.96-11.96s5.365-11.96 11.96-11.96 11.96 5.365 11.96 11.96c0 6.595-5.365 11.96-11.96 11.96z\"><\/path><\/svg><span class=\"tt\">Phone: <\/span><span class=\"tt\"><b>1-800-267-0000<\/b> <b class=\"p-l-86\">1-800-267-0001<\/b><\/span><\/div>\n<\/li>\n<li class=\" p-l-0\">\n<div class=\"tt\"><svg class=\"icon icon-black-envelope\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\"><title>black-envelope<\/title><path d=\"M2.531 6.124l11.526 9.13c0.523 0.414 1.243 0.597 1.942 0.563 0.698 0.034 1.419-0.148 1.941-0.563l11.526-9.13c0.924-0.727 0.715-1.323-0.457-1.323h-26.019c-1.173 0-1.382 0.596-0.461 1.323z\"><\/path><path d=\"M30.3 8.533l-12.596 9.563c-0.471 0.354-1.088 0.526-1.702 0.518-0.616 0.008-1.233-0.165-1.704-0.518l-12.598-9.563c-0.935-0.709-1.7-0.329-1.7 0.844v15.69c0 1.173 0.96 2.133 2.133 2.133h27.734c1.173 0 2.133-0.96 2.133-2.133v-15.69c0-1.173-0.765-1.553-1.7-0.844z\"><\/path><\/svg><a href=\"mailto:info@dentco.net\">info@dentco.net<\/a><\/div>\n<\/li>\n<\/ul>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner rsclass=&#8221;clean&#8221;][vc_column_inner el_class=&#8221;question-box mt-3&#8243; rsclass=&#8221;clean&#8221;][vc_custom_heading text=&#8221;Ask the Experts&#8221; font_container=&#8221;tag:h5|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221; rs_decor_place=&#8221;2&#8243; el_class=&#8221;question-box-title&#8221;][\/vc_custom_heading]\n<div class=\"wpcf7 no-js\" id=\"wpcf7-f246-o1\" lang=\"en-US\" dir=\"ltr\" data-wpcf7-id=\"246\">\n<div class=\"screen-reader-response\"><p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/p> <ul><\/ul><\/div>\n<form action=\"\/en\/wp-json\/wp\/v2\/pages\/5505#wpcf7-f246-o1\" method=\"post\" class=\"wpcf7-form init\" aria-label=\"Contact form\" novalidate=\"novalidate\" data-status=\"init\">\n<div style=\"display: none;\">\n<input type=\"hidden\" name=\"_wpcf7\" value=\"246\" \/>\n<input type=\"hidden\" name=\"_wpcf7_version\" value=\"6.0.4\" \/>\n<input type=\"hidden\" name=\"_wpcf7_locale\" value=\"en_US\" \/>\n<input type=\"hidden\" name=\"_wpcf7_unit_tag\" value=\"wpcf7-f246-o1\" \/>\n<input type=\"hidden\" name=\"_wpcf7_container_post\" value=\"0\" \/>\n<input type=\"hidden\" name=\"_wpcf7_posted_data_hash\" value=\"\" \/>\n<input type=\"hidden\" name=\"_wpcf7_recaptcha_response\" value=\"\" \/>\n<\/div>\n<div class=\"contact-form contact7__custom-form questionForm ws-form-icons7\" id=\"questionForm\">\n\t<div class=\"input-group\">\n\t\t<p><span class=\"wpcf7-form-control-wrap\" data-name=\"your-name\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text form-control\" aria-invalid=\"false\" placeholder=\"Your name\" value=\"\" type=\"text\" name=\"your-name\" \/><\/span>\n\t\t<\/p>\n\t<\/div>\n\t<div class=\"row row-xs-space7 mt-0 mt-md-1\">\n\t\t<div class=\"col-sm-6\">\n\t\t\t<div class=\"input-group\">\n\t\t\t\t<p><span class=\"wpcf7-form-control-wrap\" data-name=\"your-email\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-email wpcf7-text wpcf7-validates-as-email form-control\" aria-invalid=\"false\" placeholder=\"Your e-mail\" value=\"\" type=\"email\" name=\"your-email\" \/><\/span>\n\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<div class=\"col-sm-6\">\n\t\t\t<div class=\"input-group\">\n\t\t\t\t<p><span class=\"wpcf7-form-control-wrap\" data-name=\"your-phone\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text form-control\" aria-invalid=\"false\" placeholder=\"Phone\" value=\"\" type=\"text\" name=\"your-phone\" \/><\/span>\n\t\t\t\t<\/p>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\t<div class=\"mt-0 mt-md-1\">\n\t\t<p><span class=\"wpcf7-form-control-wrap\" data-name=\"your-message\"><textarea cols=\"40\" rows=\"10\" maxlength=\"2000\" class=\"wpcf7-form-control wpcf7-textarea wpcf7-validates-as-required form-control form-control-textarea\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Question*\" name=\"your-message\"><\/textarea><\/span>\n\t\t<\/p>\n\t<\/div>\n\t<div class=\"form-ask_btn_c\">\n\t\t<div class=\"mt-2\">\n\t\t\t<p><input class=\"wpcf7-form-control wpcf7-submit has-spinner btn btn-fill\" type=\"submit\" value=\"Send question\" \/>\n\t\t\t<\/p>\n\t\t<\/div>\n\t<\/div>\n<\/div><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div>\n<\/form>\n<\/div>\n[\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column width=&#8221;3\/4&#8243; rsclass=&#8221;clean&#8221; el_class=&#8221;col-md-8 col-lg-9 mt-4 mt-md-0&#8243;][vc_row_inner rsclass=&#8221;clean&#8221; el_class=&#8221;pt-2 pt-md-4&#8243;][vc_column_inner rsclass=&#8221;clean&#8221;][vc_column_text rsclass=&#8221;clean&#8221;]\n<h6>In which cases should it be done?<\/h6>\n<ul>\n<li><span style=\"font-weight: 400;\"> for women with suspected non-classic congenital adrenal hyperplasia (NCAH);<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> or with consistently high levels of male sex hormones in the blood.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Congenital adrenal hyperplasia is a group of genetic disorders characterized by a defect in the synthesis of the hormone cortisol due to various gene mutations. This is most often caused by changes in the CYP21A2 gene sequence inherited from healthy parents. Clinical manifestations of the disease are associated with the type of mutations inherited and vary from asymptomatic elevation of androgens (male sex hormones) to severe adrenal insufficiency in newborns with complete virilization of the external genitalia in girls.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Adult women with suspected non-classic congenital adrenal hyperplasia (NCAH) have consistently elevated levels of male sex hormones in the blood, which may affect their chances of getting pregnant. If, when assessing the hormonal profile and performing additional examinations (a Synacthen test), the gynaecologist suspects the possibility of this diagnosis, it should be confirmed with molecular testing.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Molecular testing of the CYP21A2 gene is recommended to confirm the diagnosis and suggest appropriate treatment, as well as to examine the partner when planning pregnancy.<\/span><\/p>\n<p><b>Material:<\/b><\/p>\n<p><b>blood or saliva.<\/b><\/p>\n<p><b>Regulations:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The test can be taken at the iVF Riga Genetics Centre, Riga, Za\u013c\u0101 Street 1, 2nd floor.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The test will be completed within 2-4 weeks.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The results will be sent to you by email encoded.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Registration: +371 67111117 or you can purchase a saliva collection kit remotely at <a href=\"http:\/\/www.ivfriga-online.lv\/en\">www.ivfriga-online.lv\/en<\/a><\/span>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text rsclass=&#8221;clean&#8221;] Molecular testing of the CYP21A2 gene [\/vc_column_text][\/vc_column][\/vc_row][vc_row rsclass=&#8221;clean&#8221; el_class=&#8221;row&#8221;][vc_column width=&#8221;1\/4&#8243; rsclass=&#8221;clean&#8221; el_class=&#8221;col-md&#8221;][vc_wp_custommenu nav_menu=&#8221;64&#8243; el_class=&#8221;services-nav flex-column flex-nowrap&#8221;][vc_row_inner rsclass=&#8221;clean&#8221; el_class=&#8221;row d-flex flex-column flex-sm-row flex-md-column mt-3&#8243;][vc_column_inner el_class=&#8221;col-auto col-sm col-md-auto&#8221; rsclass=&#8221;clean&#8221; rsinner=&#8221;contact-box contact-box-1&#8243;][vc_custom_heading text=&#8221;Working Time&#8221; font_container=&#8221;tag:h5|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221; rs_decor_place=&#8221;2&#8243; el_class=&#8221;contact-box-title&#8221;][\/vc_custom_heading][vc_column_text rsclass=&#8221;clean&#8221;] Mon-Thu 08:00 &#8211; 20:00Friday 07:00 &#8211; 22:00Saturday 08:00 &#8211; 18:00 [\/vc_column_text][\/vc_column_inner][vc_column_inner el_class=&#8221;col-auto col-sm col-md-auto&#8221; rsclass=&#8221;clean&#8221; rsinner=&#8221;contact-box contact-box-2&#8243;][vc_custom_heading <\/p>\n<div class=\"btn-more-wrapper\"><a href=\"https:\/\/genetikascentrs.lv\/en\/services\/genetic-analyses\/congenital-adrenal-hyperplasia\/\" class=\"btn btn-sm btn-hover-fill\"><svg class=\"icon icon-right-arrow\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\"><title>right-arrow<\/title><path d=\"M21.548 5.088c-0.436-0.451-1.162-0.451-1.613 0-0.436 0.436-0.436 1.162 0 1.596l8.177 8.177h-26.984c-0.629 0.001-1.129 0.501-1.129 1.13s0.5 1.145 1.129 1.145h26.984l-8.177 8.162c-0.436 0.451-0.436 1.178 0 1.613 0.451 0.451 1.178 0.451 1.613 0l10.113-10.113c0.451-0.436 0.451-1.162 0-1.596l-10.113-10.114z\"><\/path><\/svg>Read More<span class=\"screen-reader-text\"> &#8220;Congenital adrenal hyperplasia:&#8221;<\/span><svg class=\"icon icon-right-arrow\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\"><title>right-arrow<\/title><path d=\"M21.548 5.088c-0.436-0.451-1.162-0.451-1.613 0-0.436 0.436-0.436 1.162 0 1.596l8.177 8.177h-26.984c-0.629 0.001-1.129 0.501-1.129 1.13s0.5 1.145 1.129 1.145h26.984l-8.177 8.162c-0.436 0.451-0.436 1.178 0 1.613 0.451 0.451 1.178 0.451 1.613 0l10.113-10.113c0.451-0.436 0.451-1.162 0-1.596l-10.113-10.114z\"><\/path><\/svg><\/a><\/div>\n","protected":false},"author":1,"featured_media":0,"parent":2967,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-5505","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.5 - 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